West Ham defenders Winston Reid and Guy Demel face fitness tests on back and thigh injuries respectively.
Ricardo Vaz Te has had surgery on a dislocated shoulder and been ruled out for three months.
Southampton are without Gaston Ramirez for at least a month due to problems relating to a dead leg he suffered before the international break.
Danny Butterfield, Jack Cork, Tadanari Lee and Frazer Richardson are out, but Nathaniel Clyne could return.
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